The effect of lycopene supplementation from different sources on prostate-specific antigen (PSA): a systematic review and meta-analysis of randomized controlled trials

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Ther Med supplement. 2022 Jan 11;64:102801. doi: 10.1016/j.ctim.2022.102801. Online ahead of print.

ABSTRACT

BACKGROUND: Prostate cancer is a major malignancy affecting men worldwide. The protective effect of dietary or supplemental lycopene on prostate cancer has been reported in several studies; however, the conclusions are equivocal.

OBJECTIVE: The aim of this study was to assess the effects of lycopene supplementation on PSA level, by conducting a systematic review and meta-analysis of randomized controlled trials.

METHODS: We searched online databases, including PubMed, Scopus, and Web of Science, up to June 9, 2020, for relevant publications. The publication search was not limited by language or date.

RESULTS: A total of 1036 records were identified in the systematic search; of these, 9 were included in the systematic review and 6 in the meta-analysis. Pooled analysis of the 6 studies showed no significant difference in PSA levels in subjects treated with lycopene or tomato extract containing lycopene (WMD = -0.12 ng/ml; 95% CI %: -0.62, 0.38 ng/ml; P=0.64) compared to control.

CONCLUSION: Overall, tomato extracts or lycopene treatment produced no significant effect on PSA levels compared to control. However, more consistent clinical trials with larger sample sizes are needed to better discern the true effect of tomato extract or lycopene on PSA levels.

PMID:35031434 | DO I:10.1016/j.ctim.2022.102801

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