Research and clinical studies are the key to change in the supplement industry


The Council for Responsible Nutrition (CRN) revealed in its 2021 Consumer Survey on Dietary Supplements that 80% of Americans use dietary supplements for natural health care.1 This statistic says a lot about the support of the nutraceutical industry, but formulators and manufacturers should never forget how easy it is sales may suddenly stop following a publication releasing data suggesting potential harm from a natural supplement.2 A negative report on a single ingredient can lead to a catastrophic drop in revenue and loss of trust with consumers. It can also have a cascading negative impact on other product lines, which becomes a big problem, especially for large established companies with multiple product lines.

However, the exact opposite can occur when the structure/functions and security claims are scientifically backed by clinical studieslike what is happening now with the coronavirus pandemic and the increased uptake of immune support supplements like vitamins D, C and zinc.1.3

With a direct correlation between clinical research and sales, as well as consumers and companies like Amazon demanding data to show the safety and efficacy of nutraceutical products, you would assume that more formulators and manufacturers would invest time and financial resources to conduct clinical studies on their products. . Unfortunately, there aren’t enough of these tests, especially in the herbal supplement industry.

The herbal supplement industry needs to change

The majority of herbal ingredient suppliers do not perform clinical trials on their formulas due to cost and time constraints. So, instead, they only support their structure/function claims on the substantiation that plant extracts have been used successfully for centuries. You can quickly spot these companies when reading about their products because all you see are general statements that the herbs in their formula are “traditionally used for…”. While these traditional use claims may be true, relying solely on them as the sole source of substantiation is irresponsible, as they do not provide any type of safety and efficacy support for the specific product they are selling.

There are also ingredient suppliers and manufacturers who attempt to take advantage of research conducted by other companies selling similar herbal formulas as a carrier for their own products. This not only discourages innovation and high quality testing in the industry, but also harms the consumer who purchases this product, because what they end up taking may be a less effective, inferior and potentially dangerous version of what has been properly tested.

In order to establish credibility for herbal use in the supplement industry, traditional use claims must be supplemented by rigorous clinical studies of the herbal product actually formulated and sold. The catalyst for change must start with the formulators. It is imperative that they choose to work only with ingredient partners who develop and clinically test their plant-based ingredients.

The Importance of Documented Proof and Manufacturing

Another key part of creating superior herbal products is that the same company that designed and tested the formula plays a role in making them. This puts a safeguard in place to ensure that the final deliverable is safe and effective. There are a handful of reputable herbal companies that follow this trifecta approach, and it’s evident in the product literature they provide to customers with their ingredient formulas.

The following detailed testing and documentation should be the standard protocol in the herbal extracts industry of what is provided to end product manufacturers/brands:

  • Safety and efficacy data on the herbal formula that was created, including human clinical studies
  • HPTLC fingerprint analysis, which authenticates which specific herb species were used. Some herbs can have over 100 species and using the wrong species can be dangerous.
  • Verification that the herbal extracts used are standardized to the claimed percentage of the active compound since the active compound is what gives the benefit.
  • Real-time and accelerated stability test data to determine product shelf life.
  • Third-party lab reports to verify the content of impurities, such as heavy metals and microbes.
  • Third party certifications such as GMP, ISO 22000, Non-GMO, Kosher, Halal and Vegan.

Transparency and the future

Karallief is a company that has become an industry leader and is paving the way for other plant-based ingredient suppliers. Karallief has always put science first and adheres to each of the strict protocols mentioned in this article.

Karallief’s diverse team of experts consists of physicians, naturopathic doctors, industry leaders in R&D and herbalists. The company also holds an exclusive partnership with a world-renowned herbal extract manufacturer and a premium research center, bringing a combined experience of over 23 years and 25 international patents within their combined groups.

Karallief has succeeded in uniting the powerful forces of nature, science and innovation, and this is evident in their clinically tested herbal formulas like Easy Climb Joint Support, KaraLiv Liver Support and KaraHeart Cardiac Support. .

To learn more about the partnership with Karallief click here.

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